Article
The Frequency and Potential Implications of HFE Genetic Variants in Children With Cystic Fibrosis.
Pediatric pulmonology - 1 Mar 2025
Huang Leslie, Lai HuiChuan J, Furuya Katryn N, Antos Nicholas J, Asfour Fadi, Boyne Kathleen L, Howenstine Michelle, Rock Michael J, Sawicki Gregory S, Gaffin Jonathan M, Worthey Elizabeth A, Farrell Philip M
Abstract excerpt
BACKGROUND: Genetic modifiers have been identified that increase the risks of lung disease and other complications, such as diabetes in people with cystic fibrosis (CF). Variants in the hemochromatosis gene (HFE) were reported in a study of adults to be associated with worse lung disease. OBJECTIVES: To ascertain the frequency of HFE variants, particularly C282Y (c.845G > A) and H63D (c.187C > G) and to determine...
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