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Article

Development of an NGS-Based Estimation of Integrated HBV DNA in Liver Biopsies and Detection in Liquid Biopsies.

Journal of medical virology - 1 Mar 2025

Liu Hsin-Ni, Lin Selena Y, Ramirez Ricardo, Chen Shin-En, Heimer Zachary R, Kubas Roman, Shieh Fwu-Shan, Kim Elena S, Liu Yuanjie, Lau Daryl T Y, Chang Ting-Tsung, Guo Haitao, Wang Zhili, Su Ying-Hsiu

Abstract excerpt

This study characterized a hepatitis B virus (HBV) hybridization-capture next-generation sequencing (HBV-NGS) assay and applied it to develop a model for estimating the integrated HBV DNA (iDNA) quantity and for HBV genetics liquid biopsy. Using HBV monomers and reconstituted cell line DNA (SNU398, Hep3B, and PLC/PRF/5), the HBV-NGS assay demonstrated high coverage uniformity, reproducibility across HBV genotypes...

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Identifiers

PMID: 40062878
DOI: 10.1002/jmv.70290
PMCID: PMC11995388

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