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Article

Noncanonical HIV drug resistance mutations: need to close existing gaps.

AIDS (London, England) - 1 Jun 2025

Inzaule Seth, Jordan Michael R, Fokam Joseph, Hamers Raph L, Paredes Roger, Crowell Trevor A, Shafer Robert W, Schapiro Jonathan, Rinke de Wit Tobias F, Charurat Manahttan, Kuritzkes Daniel R, Ndembi Nicaise

Abstract excerpt

An increasing number of people with HIV (PWH) are failing treatment without HIV drug resistance in the drug target region. While sub-optimal adherence is likely the cause of treatment failure in many PWH, resistance emerging at noncanonical (HIV drug resistance mutations occurring outside the drug target site) drug target sites is also plausible. Noncanonical drug resistance mechanisms have been identified for...

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Identifiers

PMID: 40053490
DOI: 10.1097/QAD.0000000000004170
PMCID: PMC12064380

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