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Article

Myocardial microRNAs associated with reverse remodeling in human heart failure

25 Jan 2017

Abstract excerpt

BACKGROUND: In dilated cardiomyopathies (DCMs) changes in expression of protein-coding genes are associated with reverse remodeling, and these changes can be regulated by microRNAs (miRs). We tested the general hypothesis that dynamic changes in myocardial miR expression are predictive of β-blocker-associated reverse remodeling. METHODS: Forty-three idiopathic DCM patients (mean left ventricular ejection fraction...

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PMID: 28138556
DOI: 10.1172/jci.insight.89169

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