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Unraveling the Role of Cathepsin B Variants in Polycystic Ovary Syndrome: Insights from a Case-Control Study and Computational Analyses.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Apr 2025

Sabeti Akbar-Abad Mahboobeh, Majidpour Mahdi, Sargazi Saman, Ghasemi Marzieh, Saravani Ramin

Abstract excerpt

Polycystic ovary syndrome (PCOS) occurs in women of reproductive age, impairing reproductive and metabolic processes. Variations in the cathepsin B (CTSB) gene can influence the disease prognosis by changing the activity, stability, or expression. These single-nucleotide polymorphisms (SNPs) can affect critical cellular functions like the deposition of extracellular matrix, inflammation, and tissue repair,...

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PMID: 40044993
DOI: 10.1007/s43032-025-01806-w

Genes

CTSB

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