Differential Association of Schizotypy Dimensions With Brain Structural Connectivity and Moderation by Schizophrenia Polygenic Risk.

doi:10.1093/schbul/sbae160

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Article

Differential Association of Schizotypy Dimensions With Brain Structural Connectivity and Moderation by Schizophrenia Polygenic Risk.

Schizophrenia bulletin - 4 Mar 2025

Hoffmann Jonas, Meller Tina, Maj Carlo, Hoffmann Per, Forstner Andreas J, Nöthen Markus M, Nenadić Igor

Abstract excerpt

OBJECTIVE: Schizotypy as a psychosis proneness marker has facilitated the study of schizophrenia spectrum models, linking phenotypic psychosis risk to brain structural and functional variation. However, association studies to structural connectome markers are limited and often do not consider relations to genetic risk. We tested the hypothesis that dimensions of schizotypy (rather than overall phenotype risk...

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Topics

Humans
Schizotypal Personality Disorder
Schizophrenia
Male
Female
Diffusion Tensor Imaging

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Multifactorial Inheritance

Connectome

Young Adult

White Matter

Genetic Predisposition to Disease

Adolescent

Source

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Identifiers

PMID: 40037820
DOI: 10.1093/schbul/sbae160
PMCID: PMC11879560

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