Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.

doi:10.1093/schbul/sbad143

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Article

Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects.

Schizophrenia bulletin - 4 Mar 2025

Nenadić Igor, Mosebach Johannes, Schmitt Simon, Meller Tina, Stein Frederike, Brosch Katharina, Ringwald Kai, Pfarr Julia-Katharina, Meinert Susanne, Lemke Hannah, Waltemate Lena, Thiel Katharina, Opel Nils, Repple Jonathan, Grotegerd Dominik, Steinsträter Olaf, Sommer Jens, Hahn Tim, Jansen Andreas, Dannlowski Udo, Krug Axel, Kircher Tilo

Abstract excerpt

BACKGROUND AND HYPOTHESIS: Schizotypy is a risk phenotype for the psychosis spectrum and pilot studies suggest a biological continuum underlying this phenotype across health and disease. It is unclear whether this biological continuum might include brain structural associations in networks altered in schizophrenia spectrum disorders, such as the fronto-thalamo-striatal system or nodes of the default mode network,...

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Topics

Humans
Schizotypal Personality Disorder
Male
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Adult

Thalamus

Diffusion Tensor Imaging

Young Adult

Frontal Lobe

Nerve Net

Phenotype

Adolescent

White Matter

Connectome

Psychotic Disorders

Cohort Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 40037831
DOI: 10.1093/schbul/sbad143
PMCID: PMC11879573

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