Article

Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome Studies

2025-04-23

Abstract excerpt

<h4>Summary</h4> Understanding the complex interactions between microbes and their environment requires robust model systems such as synthetic communities (SynComs). We developed a functionally directed approach to generate SynComs by selecting strains that encode key functions identified in metagenomes. This approach enables the rapid construction of SynComs tailored to any ecosystem. To optimize community desig...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eef36c44-7dcc-59c6-97f8-7fee00b08f75
DOI: 10.1101/2025.04.23.650235

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Function-Based Selection of Synthetic Communities Enables Mechanistic Microbiome StudiesDOI 10.1101/2025.04.23.650235Read

Statistical design of a synthetic microbiome that suppresses diverse gut pathogensSemantic proximity Read

A designed synthetic microbiota provides insight to community function in Clostridioides difficile resistanceSemantic proximity Read

Complete genome-derived metabolic interactions reveal impact of gut ecology on human healthSemantic proximity Read

Fecal Microbiota Transplants for Inflammatory Bowel Disease Treatment: Synthetic- and Engineered Communities-Based Microbiota Transplants Are the FutureSemantic proximity Read

A data-driven modeling framework for mapping genotypes to synthetic microbial community functions.Semantic proximity Read

Building microbial synthetic communities: get inspired by the design of synthetic plant communities.Semantic proximity Read

Systematic dissection of a complex gut bacterial communitySemantic proximity Read

Deciphering microbial interactions in synthetic human gut microbiome communitiesSemantic proximity Read

eBiota: Designing microbial communities from large seed pools with desired function using rapid optimization and deep learningSemantic proximity Read

Design of synthetic microbial consortia for gut microbiota modulationSemantic proximity Read

Identifying gut microbe-host phenotype relationships using combinatorial communities in gnotobiotic mice.Semantic proximity Read

Two Competing Guilds as a Core Microbiome Signature for Health RecoverySemantic proximity Read