Article

Statistical design of a synthetic microbiome that suppresses diverse gut pathogens

2024-02-29

Abstract excerpt

Engineering functional microbiomes is challenging due to complex interactions between bacteria and their environments 1–6 . Using a set of 848 gut commensal strains and clearance of multi-drug resistant Klebsiella pneumoniae ( Kp -MH258) as a target function, we engineered a functional 15-member synthetic microbiome—SynCom15—through a statistical approach agnostic to strain phenotype, mechanism of action, bacte...

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Literature Corpus work: d84503d7-bf01-5fff-a900-f1d668566b79
DOI: 10.1101/2024.02.28.582635

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