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Article

POLE2 facilitates the malignant phenotypes of glioblastoma through promoting AURKA-mediated stabilization of FOXM1.

Cell death & disease - 17 Jan 2022

Zhang Peng, Chen Xu, Zhang LingYun, Cao Dan, Chen Yong, Guo ZhengQian, Chen Jian

Abstract excerpt

Glioblastoma (GBM) is a type of brain cancer with high morbidity and mortality worldwide. The clinical significance, biological roles, and underlying molecular mechanisms of DNA poly ε-B subunit (POLE2) in GBM were investigated in the study. Firstly, the Cancer Genome Atlas (TCGA) database found that POLE2 was highly expressed in GBM. Immunohistochemistry (IHC) results further confirmed that POLE2 was abnormally...

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Identifiers

PMID: 35039475
DOI: 10.1038/s41419-021-04498-7
PMCID: PMC8763902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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