Article
The impact of common and rare genetic variants on bradyarrhythmia development.
Nature genetics - 1 Jan 2025
Weng Lu-Chen, Rämö Joel T, Jurgens Sean J, Khurshid Shaan, Chaffin Mark, Hall Amelia Weber, Morrill Valerie N, Wang Xin, Nauffal Victor, Sun Yan V, Beer Dominik, Lee Simon, Nadkarni Girish N, Duong ThuyVy, Wang Biqi, Czuba Tomasz, Austin Thomas R, Yoneda Zachary T, Friedman Daniel J, Clayton Anne, Hyman Matthew C, Judy Renae L, Skanes Allan C, Orland Kate M, Treu Timothy M, Oetjens Matthew T, Alonso Alvaro, Soliman Elsayed Z, Lin Honghuang, Lunetta Kathryn L, van der Pals Jesper, Issa Tariq Z, Nafissi Navid A, May Heidi T, Leong-Sit Peter, Roselli Carolina, Choi Seung Hoan, Khan Habib R, Knight Stacey, Karlsson Linnér Richard, Bezzina Connie R, Ripatti Samuli, Heckbert Susan R, Gaziano J Michael, Loos Ruth J F, Psaty Bruce M, Smith J Gustav, Benjamin Emelia J, Arking Dan E, Rader Daniel J, Shah Svati H, Roden Dan M, Damrauer Scott M, Eckhardt Lee L, Roberts Jason D, Cutler Michael J, Shoemaker M Benjamin, Haggerty Christopher M, Cho Kelly, Palotie Aarno, Wilson Peter W F, Ellinor Patrick T, Lubitz Steven A
Abstract excerpt
To broaden our understanding of bradyarrhythmias and conduction disease, we performed common variant genome-wide association analyses in up to 1.3 million individuals and rare variant burden testing in 460,000 individuals for sinus node dysfunction (SND), distal conduction disease (DCD) and pacemaker (PM) implantation. We identified 13, 31 and 21 common variant loci for SND, DCD and PM, respectively. Four...
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