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UV Protection in the Cornea: Failure and Rescue

10 Feb 2022

Abstract excerpt

Ultraviolet (UV) irradiation induces DNA lesions in all directly exposed tissues. In the human body, two tissues are chronically exposed to UV: the skin and the cornea. The most frequent UV-induced DNA lesions are cyclobutane pyrimidine dimers (CPDs) that can lead to apoptosis or induce tumorigenesis. Lacking the protective pigmentation of the skin, the transparent cornea is particularly dependent on nucleotide...

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PMID: 35205145
DOI: 10.3390/biology11020278

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