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Article

Photodamage: all signs lead to actinic keratosis and early squamous cell carcinoma.

Current problems in dermatology - 1 Jan 2015

Wei Jerry, Kok Lai Fong, Byrne Scott N, Halliday Gary M

Abstract excerpt

Ultraviolet (UV) radiation is likely to drive the initiation and progression of skin cancer from actinic keratosis to squamous cell carcinoma. Signs of photodamage occur at multiple steps. UV radiation damages many cellular constituents, including lipids, proteins and DNA, all of which are likely to contribute to UV-induced skin cancer. Two biological events culminating from photodamage are mutations in the genes...

Read the complete abstract on PubMed

Topics

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Share to Carcinogenesis
Share to Carcinoma, Squamous Cell
Share to Immunity, Cellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasms, Radiation-Induced

Share to Skin Neoplasms

Share to T-Lymphocytes, Regulatory

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Source

Identifiers

PMID: 25561201
DOI: 10.1159/000366531

Genes

HRAS
PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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