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Article

Evidence of a novel gene locus ARHGAP44 for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study.

Physiological genomics - 1 May 2025

Wang Siyu, Lenzini Petra, Thyagarajan Bharat, Lee Joseph H, Vardarajan Badri N, Yashin Anatoli, Miljkovic Iva, Daw E Warwick, Lin Shiow J, Patti Gary J, Brent Michael R, Zmuda Joseph M, Perls Thomas T, Christensen Kaare, Province Michael A, An Ping

Abstract excerpt

Glycated hemoglobin A1c (HbA1c) indicates average glucose levels over 3 mo and is associated with insulin resistance and type 2 diabetes (T2D). Longitudinal change in circulating HbA1c (ΔHbA1c) is also associated with aging processes, cognitive performance, and mortality. We analyzed ΔHbA1c in 1,886 nondiabetic Europeans from the Long Life Family Study (LLFS) to uncover gene loci influencing ΔHbA1c. Using growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40019798
DOI: 10.1152/physiolgenomics.00137.2024
PMCID: PMC12182963

Genes

ARHGAP44
FOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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