Development of a reverse genetic system for mononegaviruses using a circular polymerase extension reaction

Abstract excerpt

Reverse genetic systems are commonly used to study viruses; the ability to rapidly generate recombinant viruses is critical for studying the functions of viral genes and for the development of new interventions, such as antivirals or vaccines. Reverse genetic methods for mononegaviruses, viruses with non-segmented negative-strand RNA genomes, commonly incorporate a full-length viral genome cDNA into a bacterial...

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