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Article

Pancreatic Cancer Risk and Screening Outcomes in Li-Fraumeni Syndrome.

Pancreas - 1 Aug 2025

Fernandes Conrad J, Du Yun K, Naumer Anne, Kagami Laura A, Le Anh, Good Madeline, Duvall Melani, Powers Jacquelyn, Zelley Kristin, Maese Luke D, MacFarland Suzanne, Kohlmann Wendy, Maxwell Kara N, Katona Bryson W

Abstract excerpt

OBJECTIVES: Li-Fraumeni syndrome (LFS) is a cancer predisposition syndrome that may confer increased pancreatic cancer (PC) risk. This study assesses PC risk and the rate of pancreatic imaging abnormalities in LFS. METHODS: PC prevalence in LFS was calculated for individuals with a known TP53 variant from the IARC/NCI database. Pancreatic imaging studies across 3 institutional LFS cohorts were reviewed and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40009039
DOI: 10.1097/MPA.0000000000002483

Genes

PC
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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