Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

doi:10.1001/jamaoncol.2017.1968

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Article

Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.

JAMA oncology - 1 Dec 2017

Ballinger Mandy L, Best Ana, Mai Phuong L, Khincha Payal P, Loud Jennifer T, Peters June A, Achatz Maria Isabel, Chojniak Rubens, Balieiro da Costa Alexandre, Santiago Karina Miranda, Garber Judy, O'Neill Allison F, Eeles Rosalind A, Evans D Gareth, Bleiker Eveline, Sonke Gabe S, Ruijs Marielle, Loo Claudette, Schiffman Joshua, Naumer Anne, Kohlmann Wendy, Strong Louise C, Bojadzieva Jasmina, Malkin David, Rednam Surya P, Stoffel Elena M, Koeppe Erika, Weitzel Jeffrey N, Slavin Thomas P, Nehoray Bita, Robson Mark, Walsh Michael, Manelli Lorenzo, Villani Anita, Thomas David M, Savage Sharon A

Abstract excerpt

Importance: Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (WBMRI) may play a role in surveillance of this high-risk population. Objective: To assess the clinical utility of WBMRI in germline TP53 mutation carriers at baseline. Data Sources: Clinical and research surveillance cohorts were identified...

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PMID: 28772291
DOI: 10.1001/jamaoncol.2017.1968
PMCID: PMC5824277

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