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Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer

16 Dec 2021

Abstract excerpt

Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors for the treatment of ovarian and breast cancers has advanced research on other PARP family members for the treatment of cancer. This paper reviews the role of...

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PMID: 34976832
DOI: 10.3389/fonc.2021.790967

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