Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow

Abstract excerpt

This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to affinity-enrich antigenic proteins in biochemically fractionated pools of bacterial proteins, followed by their identification and quantification using mass spectrometry. A...

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