Article
Immunological fingerprinting of group B streptococci: from circulating human antibodies to protective antigens.
Vaccine - 8 Oct 2010
Meinke Andreas L, Senn Beatrice M, Visram Zehra, Henics Tamás Z, Minh Duc Bui, Schüler Wolfgang, Neubauer Christina, Gelbmann Dieter, Noiges Birgit, Sinzinger Jan, Hanner Markus, Dewasthaly Shailesh, Lundberg Urban, Hordnes Knut, Masoud Helga, Sevelda Paul, von Gabain Alexander, Nagy Eszter
Abstract excerpt
Group B streptococcus is one of the most important pathogens in neonates, and causes invasive infections in non-pregnant adults with underlying diseases. Applying a genomic approach that relies on human antibodies we identified antigenic GBS proteins, among them most of the previously published protective antigens. In vitro analyses allowed the selection of conserved candidate antigens that were further evaluated...
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