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Article

Context-dependent change in the fitness effect of (in)organic phosphate antiporter glpT during Salmonella Typhimurium infection.

Nature communications - 24 Feb 2025

Santamaria de Souza Noemi, Cherrak Yassine, Andersen Thea Bill, Vetsch Michel, Barthel Manja, Kroon Sanne, Bakkeren Erik, Schubert Christopher, Christen Philipp, Kiefer Patrick, Vorholt Julia A, Nguyen Bidong D, Hardt Wolf-Dietrich

Abstract excerpt

Salmonella enterica is a frequent cause of foodborne diseases, which is attributed to its adaptability. Even within a single host, expressing a gene can be beneficial in certain infection stages but neutral or even detrimental in others as previously shown for flagellins. Mutants deficient for the conserved glycerol-3-phosphate and phosphate antiporter glpT have been shown to be positively selected in nature,...

Read the complete abstract on PubMed

Topics

Salmonella typhimurium
Animals
Mice
Bacterial Proteins
Phosphates

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Salmonella Infections

Antiporters

Mutation

Mice, Inbred C57BL

Female

Source

Open in PubMed Open full text

Identifiers

PMID: 39994176
DOI: 10.1038/s41467-025-56851-5
PMCID: PMC11850910

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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