Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept.

doi:10.1111/tan.70057

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Article

Four Target Resequencing for the Bovine Major Histocompatibility Complex Region. Proof of Concept.

HLA - 1 Feb 2025

Giovambattista Guillermo, Kawamura Arisa, Ishida Akane, Murakawa Yukine, Hosomichi Kazuyoshi, Nagata Fumihiro, Aida Yoko, Takeshima Shin-Nosuke

Abstract excerpt

The bovine leukocyte antigen (BoLA) comprises four regions that contain a high density of polymorphic genes and frequently show gene copy number variations (CNV). Therefore, genotyping BoLA using genome-wide resequencing is difficult. This study aimed to develop four probe sets for resequencing of the BoLA region using a hybridization capture target next-generation sequencing (NGS) method. This proof of concept...

Read the complete abstract on PubMed

Topics

Animals
Cattle
Polymorphism, Single Nucleotide
High-Throughput Nucleotide Sequencing
Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA Copy Number Variations

Genotype

Sequence Analysis, DNA

Proof of Concept Study

Genotyping Techniques

Polymerase Chain Reaction

Major Histocompatibility Complex

Alleles

INDEL Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39991974
DOI: 10.1111/tan.70057
PMCID: PMC11848996

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