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Article

Causal Relationship Between Gut Microbiota, Metabolites, and Sarcopenia: A Mendelian Randomization Study.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Sept 2024

Zhang Xiangyu, Yang Guang, Jiang Shide, Ji Bingzhou, Xie Wenqing, Li Hengzhen, Sun Jianfeng, Li Yusheng

Abstract excerpt

BACKGROUND: Gut microbiota imbalance and sarcopenia are frequently observed in older adults. Gut microbiota and their metabolites are considered risk factors contributing to the heightened risk of sarcopenia, but whether these associations are causal remains unclear. METHODS: We conducted linkage disequilibrium score regression and 2-sample Mendelian randomization (MR) methods with single-nucleotide polymorphisms...

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Identifiers

PMID: 38995073
DOI: 10.1093/gerona/glae173
PMCID: PMC11329623

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