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Article

The association of the placental CASPASE-3 gene polymorphisms and preeclampsia susceptibility and in-silico analysis.

Journal of cellular biochemistry - 1 Aug 2018

Teimoori Batool, Yazdi Atefeh, Rezaei Mahnaz, Mohammadpour-Gharehbagh Abbas, Jahantigh Danial, Salimi Saeedeh

Abstract excerpt

Preeclampsia is a pathologic complication of pregnancy, associated with increased apoptosis in the cytotrophoblasts as the main cause of this disorder. Caspase-3 is a key apoptosis-related enzyme that both mitochondrial and death receptor apoptotic pathways can activate. In this study, we aimed to investigate the effect of placental CASP-3 rs4647602 and rs4647610 polymorphisms on PE susceptibility. The placentas...

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PMID: 29737550
DOI: 10.1002/jcb.26869

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