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Article

Conversion of Optineurin into an Hsp72-Inducible protein by C-terminal addition of green fluorescent protein.

Molecular vision - 1 Jan 2024

Suh Wool, Sohn Seongsoo, Kim Tae Eun, Kee Changwon

Abstract excerpt

Purpose: Optineurin is known to be associated with glaucoma. This protein has often been investigated as a form of fusion with green fluorescent protein (GFP), but there have been few reports describing any undesired effect of the tag on the normal expression of naïve optineurin. We investigated whether GFP tagging potentially does not influence the characteristics of optineurin expression. Methods: Wild-type and...

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Identifiers

PMID: 39959175
PMCID: PMC11829791

Genes

OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Conversion of Optineurin into an Hsp72-Inducible protein by C-terminal addition of green fluorescent protein.PMID 39959175Read ↗

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Defects in autophagy caused by glaucoma-associated mutations in optineurin.Semantic proximity Read ↗

A novel optinEuRin stress connection in glaucoma.Semantic proximity Read ↗

Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Semantic proximity Read ↗

Oligomerization of optineurin and its oxidative stress- or E50K mutation-driven covalent cross-linking: possible relationship with glaucoma pathology.Semantic proximity Read ↗

Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin geneSemantic proximity Read ↗

A glaucoma‐associated OPTN polymorphism, M98K sensitizes retinal cells to endoplasmic reticulum stress and tumour necrosis factor αSemantic proximity Read ↗

A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants.Semantic proximity Read ↗

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