Article
Impairment of protein trafficking upon overexpression and mutation of optineurin.
PloS one - 12 Jul 2010
Park BumChan, Ying Hongyu, Shen Xiang, Park Jeong-Seok, Qiu Ye, Shyam Rajalekshmy, Yue Beatrice Y J T
Abstract excerpt
BACKGROUND: Glaucoma is a major blinding disease characterized by progressive loss of retinal ganglion cells (RGCs) and axons. Optineurin is one of the candidate genes identified so far. A mutation of Glu(50) to Lys (E50K) has been reported to be associated with a more progressive and severe disease. Optineurin, known to interact with Rab8, myosin VI and transferrin receptor (TfR), was speculated to have a role...
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