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A rhodamine-coordinated iridium complex to overcome cisplatin-resistant cancer via regulating mitochondrial function triggered apoptosis and ferroptosis

10 Feb 2025

Abstract excerpt

Modulating mitochondrial activity to regulate cancer cell homeostatic recycling presents a promising approach to overcome tumor resistance. Consequently, there is an urgent need for novel mitochondria-targeting agents and innovative strategies. We have developed [((η 5 -Cp∗)Ir(rhod)] 2+ 2PF 6 − ( Ir-rhod ), a new mitochondria-targeted iridium complex that exhibits greater cytotoxicity towards A549R...

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Share to Advanced biosensing and bioanalysis techniques
Share to Ferroptosis and cancer prognosis
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PMID: 39956024
DOI: 10.1016/j.redox.2025.103536

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