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Article

A dual-targeting, apoptosis-inducing organometallic half-sandwich iridium anticancer complex

1 Jan 2014

Abstract excerpt

The cellular mechanism of action of an iridium(III) half-sandwich complex [(η(5)-C5Me4C6H4C6H5)Ir(phen)Cl]PF6 (phen = phenanthroline) (1) is reported. Complex 1 was used to treat several cell lines, including cisplatin-sensitive, cisplatin-resistant (with intrinsic and acquired resistance) carcinoma cells with wild type p53 status as well as the cells with no intact p53 gene, and nontumorigenic cells. Complex 1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24828756
DOI: 10.1039/c4mt00112e

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