Mitaplatin Increases Sensitivity of Tumor Cells to Cisplatin by Inducing Mitochondrial Dysfunction

Abstract excerpt

Tumor resistance to chemotherapy is the major obstacle to employ cisplatin, one of the broadly used chemotherapeutic drugs, for effective treatment of various tumors in the clinic. Most acknowledged mechanisms of cancer resistance to cisplatin focus on increased nuclear DNA repair or detoxicity of cisplatin. We previously demonstrated that there was a unique metabolic profile in cisplatin-resistant (CP-r) human...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to ATP Synthase and ATPases Research
• Share to Cancer therapeutics and mechanisms
• Share to Metal complexes synthesis and properties