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Article

Imaging Clusters of Pediatric Low-Grade Glioma Are Associated with Distinct Molecular Characteristics.

AJNR. American journal of neuroradiology - 1 Aug 2025

Fathi Kazerooni Anahita, Kraya Adam, Rathi Komal S, Kim Meen Chul, Kesherwani Varun, Corbett Ryan, Vossough Arastoo, Khalili Nastaran, Gandhi Deep, Khalili Neda, Familiar Ariana M, Jin Run, Huang Xiaoyan, Zhu Yuankun, Sickler Alex, Lueder Matthew R, Phul Saksham, Storm Phillip B, Ware Jeffrey B, Foster Jessica B, Mueller Sabine, Rokita Jo Lynne, Fisher Michael J, Resnick Adam C, Nabavizadeh Ali

Abstract excerpt

BACKGROUND AND PURPOSE: Cancers show heterogeneity at various levels, from genome to radiologic imaging. This study aimed to explore the interplay between genomic, transcriptomic, and radiophenotypic data in pediatric low-grade glioma (pLGG), the most common group of brain tumors in children. MATERIALS AND METHODS: We analyzed data from 201 patients with pLGG in the Children's Brain Tumor Network by using...

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Identifiers

PMID: 39952665
DOI: 10.3174/ajnr.A8699
PMCID: PMC12453517

Genes

BRAF
KIAA1549
PDGFRB

Variants

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