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Host adaptation in Salmonella enterica serovar Typhimurium: population structure, pathovariants, and genomic mechanisms.

Applied and environmental microbiology - 18 Mar 2026

Gong Hairuo, Wu Qiuhui, Xu Mengnan, Meng Wenzhe, Wang Yunfei, Ju Changyan, Fu Yezhi

Abstract excerpt

Salmonella enterica serovar Typhimurium is a major zoonotic pathogen of global concern to human and animal health. With its broad host range, this serovar can colonize humans as well as domesticated and wild animals. Although historically considered a model host-generalist pathogen, whole-genome sequencing (WGS) has uncovered substantial genetic diversity and the emergence of multiple host-adapted pathovariants...

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PMID: 41665349
DOI: 10.1128/aem.02201-25
PMCID: PMC12997813

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