Genomic Analysis of Salmonella enterica Serovar Typhimurium Characterizes Strain Diversity for Recent U.S. Salmonellosis Cases and Identifies Mutations Linked to Loss of Fitness under Nitrosative and Oxidative Stress.

doi:10.1128/mBio.00154-16

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Genomic Analysis of Salmonella enterica Serovar Typhimurium Characterizes Strain Diversity for Recent U.S. Salmonellosis Cases and Identifies Mutations Linked to Loss of Fitness under Nitrosative and Oxidative Stress.

mBio - 8 Mar 2016

Hayden Hillary S, Matamouros Susana, Hager Kyle R, Brittnacher Mitchell J, Rohmer Laurence, Radey Matthew C, Weiss Eli J, Kim Katie B, Jacobs Michael A, Sims-Day Elizabeth H, Yue Min, Zaidi Mussaret B, Schifferli Dieter M, Manning Shannon D, Walson Judd L, Miller Samuel I

Abstract excerpt

UNLABELLED: Salmonella enterica serovar Typhimurium is one of the most common S. enterica serovars associated with U.S. foodborne outbreaks. S. Typhimurium bacteria isolated from humans exhibit wide-ranging virulence phenotypes in inbred mice, leading to speculation that some strains are more virulent in nature. However, it is unclear whether increased virulence in humans is related to organism characteristics or...

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PMID: 26956590
DOI: 10.1128/mBio.00154-16
PMCID: PMC4810482

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