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Article

SIRT3 impairment and MnSOD hyperacetylation in trophoblast dysfunction and preeclampsia

10 Feb 2025

Abstract excerpt

Preeclampsia (PE) is a prevalent obstetric disorder that affects 2–8 % of pregnancies worldwide. Trophoblasts, which are crucial functional cells in the placenta, play a significant role in the development of PE due to inadequate invasion. Sirtuin 3 (SIRT3) is an NAD + − dependent mitochondrial deacetylase, that positively modulates energy metabolism, mitochondrial biogenesis, and protection against oxidative...

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PMID: 39938691
DOI: 10.1016/j.bbamcr.2025.119915

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