Article
The association between obstructive sleep apnea and frailty traits: a bidirectional Mendelian randomization study.
BMC pulmonary medicine - 16 Feb 2026
Huang Jingning, Chu Yunqiu, Zhang Xiaozhen, Shen Zilu, Li Chenyang, Li Xinyi, Liu Yupu, Zou Jianyin, Liu Suru, Wu Kejia, Huang Weijun, Zhang Xiaoman, Xu Huajun, Guan Jian, Yi Hongliang, Zhu Xiaoyue, Yin Shankai
Abstract excerpt
BACKGROUND: This study aimed to explore the causal association between obstructive sleep apnea (OSA) and frailty traits using a bidirectional two-sample Mendelian randomization (MR) analysis. METHODS: Summary data from large-scale European genome-wide association studies were used to assess the g...
Topics
- Humans
- Sleep Apnea, Obstructive
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
- Genome-Wide Association Study
- Frailty
- Hand Strength
- Walking Speed