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Article

Severe COVID-19 disease is associated with genetic factors affecting plasma ACE2 receptor and CRP concentrations.

Scientific reports - 8 Feb 2025

Vogi Verena, Haschka David, Forer Lukas, Schwendinger Simon, Petzer Verena, Coassin Stefan, Tancevski Ivan, Sonnweber Thomas, Löffler-Ragg Judith, Puchhammer-Stöckl Elisabeth, Graninger Marianne, Wolf Dominik, Kronenberg Florian, Zschocke Johannes, Jukic Emina, Weiss Günter

Abstract excerpt

A hyperinflammatory state with highly elevated concentrations of inflammatory biomarkers such as C-reactive protein (CRP) is a characteristic feature of severe coronavirus disease 2019 (COVID-19). To examine a potential role of common genetic factors that may influence COVID-19 outcomes, we investigated whether individuals with a polygenic predisposition for a pro-inflammatory response (in the form of Polygenic...

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Identifiers

PMID: 39922945
DOI: 10.1038/s41598-025-89306-4
PMCID: PMC11807156

Genes

CRP
ACE2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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