Article
SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT activation.
Scientific reports - 8 Feb 2025
Zhang Liangying, Xiao Kun, Zhang Shaoting, Zhao Sien, Liu Zimei, Wang Ming, Qin Kaiyue, Yu Yuanyuan, Li Shujing, Ma Lijun, Sun Jianmin
Abstract excerpt
The suppressors of cytokine signaling 2 (SOCS2) inhibits growth hormone receptor (GHR) signaling by negative feedback in the regulation of metabolism. In this study, we found that GHR upregulates SOCS2 expression, whereas KIT mutations, the key driver mutations of gastrointestinal stromal tumors (GISTs), inhibits SOCS2 expression in GISTs. Furthermore, SOCS2 associated and inhibited the activation of KIT...
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