Article
The ICAM1 p.K56M variant and risk of heart failure in chronic kidney disease: the Chronic Renal Insufficiency Cohort study.
Heart (British Cardiac Society) - 2 May 2025
Culler Kasen, Zelnick Leila R, Mehta Rupal C, de Sosa Giselle R, Kansal Mayank, Rao Panduranga S, Bhat Zeenat, Taliercio Jonathan, Horwitz Edward, Chen Jing, He Jiang, Shah Sanjiv J, Isakova Tamara, Patel Ravi B
Abstract excerpt
BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) is a cell-surface protein that facilitates inflammation through leucocyte adhesion. Approximately 35% of Black individuals carry at least one copy of an ICAM1 missense variant (rs5491; p.K56M), which has been associated with increased risk of heart failure (HF) with preserved ejection fraction (HFpEF). Whether the risk of HFpEF conferred by rs5491 extends to...
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