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Article

Missense Genetic Variation of ICAM1 and Incident Heart Failure.

Journal of cardiac failure - 1 Aug 2023

Giro Pedro, Cunningham Jonathan W, Rasmussen-Torvik Laura, Bielinski Suzette J, Larson Nicholas B, Colangelo Laura A, Jacobs David R, Gross Myron, Reiner Alex P, Lloyd-Jones Donald M, Guo Xiuqing, Taylor Kent, Vaduganathan Muthiah, Post Wendy S, Bertoni Alain, Ballantyne Christie, Shah Amil, Claggett Brian, Boerwinkle Eric, Yu Bing, Solomon Scott D, Shah Sanjiv J, Patel Ravi B

Abstract excerpt

BACKGROUND: Intercellular adhesion molecule-1 (ICAM-1) is a cell surface protein that participates in endothelial activation and is hypothesized to play a central role in heart failure (HF). We evaluated associations of ICAM1 missense genetic variants with circulating ICAM-1 levels and with incident HF. METHODS AND RESULTS: We identified 3 missense variants within ICAM1 (rs5491, rs5498 and rs1799969) and...

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Source

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Identifiers

PMID: 36882149
DOI: 10.1016/j.cardfail.2023.02.003
PMCID: PMC10477308

Genes

ICAM1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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