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Article

Harnessing Metabolic Priming to Engineer Human Nucleus Pulposus Macromass Overcoming Scalability-Phenotype Tradeoff.

Cell proliferation - 1 Sept 2026

Wang Yingbo, Hu Ou, Wu Jian, Huang Sha, Lin Peng, Yan Pulin, Li Yangyang, Jin Huaijian, Wu Yutong, Zhu Jun, Pu Jungang, Hu Bo, He Jian, Gan Yibo, Liu Peng

Abstract excerpt

Intervertebral disc degeneration (IDD) represents a major global health challenge, primarily due to the inability of current therapies to reverse the progressive loss of nucleus pulposus (NP) tissue and function. Transplanting bioactive substitutes offers potential for overcoming this limitation. However, current strategies fail to generate large-sized, functional human NP substitutes, impeded by a fundamental...

Read the complete abstract on PubMed

Topics

Humans
Nucleus Pulposus
Collagen Type II
Aggrecans
Cell Proliferation
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Tissue Engineering

Animals

Intervertebral Disc Degeneration

Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 42049200
DOI: 10.1111/cpr.70215
PMCID: PMC13326001

Genes

ACAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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