Association between the COX-2 rs689466 polymorphism and antipsychotic treatment: Impact on HDL cholesterol changes in clozapine-treated psychosis patients.

doi:10.1016/j.plefa.2025.102665

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Association between the COX-2 rs689466 polymorphism and antipsychotic treatment: Impact on HDL cholesterol changes in clozapine-treated psychosis patients.

Prostaglandins, leukotrienes, and essential fatty acids - 1 Apr 2025

Nadalin Sergej, Ljoka Ivan, Savić Aleksandar, Silić Ante, Peitl Vjekoslav, Karlović Dalibor, Vilibić Maja, Zatković Lena, Buretić-Tomljanović Alena

Abstract excerpt

Several studies have shown antipsychotic effects of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib as an add-on treatment to antipsychotic treatment. The functional rs689466 (A/G) polymorphism in the gene encoding COX-2 (also known as the prostaglandin-endoperoxide synthase 2 gene) has been correlated with schizophrenia risk and the niacin skin flush response among chronic patients under antipsychotic...

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PMID: 39908800
DOI: 10.1016/j.plefa.2025.102665

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