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Article

TMBocelot: an omnibus statistical control model optimizing the TMB thresholds with systematic measurement errors.

Frontiers in immunology - 1 Jan 2024

Lai Xin, Wang Shaoliang, Zhang Xuanping, Zhu Xiaoyan, Liu Yuqian, Chang Zhili, Wang Xiaonan, Shao Yang, Wang Jiayin, Wang Yixuan

Abstract excerpt

Tumor mutation burden (TMB), defined as the number of somatic mutations of tumor DNA, is a well-recognized immunotherapy biomarker endorsed by regulatory agencies and pivotal in stratifying patients for clinical decision-making. However, measurement errors can compromise the accuracy of TMB assessments and the reliability of clinical outcomes, introducing bias into statistical inferences and adversely affecting...

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Identifiers

PMID: 39902037
DOI: 10.3389/fimmu.2024.1514295
PMCID: PMC11788372

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