Article

Methodological and Clinical Validation of TholdStormDX v0.0.1: An Advanced Stochastic Engine for the Optimization of Thresholds and Multimarker Panels Applied to Oncology

2026-04-27

Abstract excerpt

<h4>Introduction</h4> The translation of biomarkers into binary clinical decisions requires the determination of precise cut-off points. This study validates the TholdStormDX v0.0.1 tool, a mathematical engine that employs Dual Annealing, 2- and 4-parameter logistic fitting, and vectorized Monte Carlo simulations for panel optimization under Boolean OR logic. <h4>Methods</h4> The tool was evaluated using datas...

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Literature Corpus work: 51509671-0ba9-55f7-b4b6-677fdd2d15bd
DOI: 10.64898/2026.04.24.26351692

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