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Article

TMBcat: A multi-endpoint p-value criterion on different discrepancy metrics for superiorly inferring tumor mutation burden thresholds.

Frontiers in immunology - 1 Jan 2022

Wang Yixuan, Lai Xin, Wang Jiayin, Xu Ying, Zhang Xuanping, Zhu Xiaoyan, Liu Yuqian, Shao Yang, Zhang Li, Fang Wenfeng

Abstract excerpt

Tumor mutation burden (TMB) is a widely recognized stratification biomarker for predicting the efficacy of immunotherapy; however, the number and universal definition of the categorizing thresholds remain debatable due to the multifaceted nature of efficacy and the imprecision of TMB measurements. We proposed a minimal joint p-value criterion from the perspective of differentiating the comprehensive therapeutic...

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Identifiers

PMID: 36189291
DOI: 10.3389/fimmu.2022.995180
PMCID: PMC9523486

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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