Article
Effect of Brief Electrical Stimulation on Cell Biomechanics in Hereditary Sensory Neuropathy.
Small (Weinheim an der Bergstrasse, Germany) - 1 Mar 2025
Ta Daniel, Anthony Anu, Sliow Ashour, Wan Boyang, Zhang Leo, Higgins Michael, Lam Lisa, Mahns David, Gargiulo Gaetano, Breen Paul, Mawad Damia, Ruprai Herleen, Myers Simon, Laurenti Daunia, Lauto Antonio
Abstract excerpt
SH-SY5Y neuroblastoma cells are widely used to model neurodegenerative disorders like Alzheimer's, Parkinson's, Huntington's, and Hereditary Sensory Neuropathy type 1A (HSN-1A), a peripheral nerve condition causing axon degeneration and sensory loss. A cell model of HSN-1A is developed by overexpressing wild-type and mutant SPTLC1 genes (C133W, C133Y, V144D). Cells are cultured on plastic and gold substrates,...
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