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Accelerated Cellular Senescence in Progressive Multiple Sclerosis: A Histopathological Study

1 Feb 2025

Abstract excerpt

Objective The neurodegenerative processes driving the build‐up of disability in progressive multiple sclerosis (P‐MS) have not been fully elucidated. Recent data link cellular senescence (CS) to neurodegeneration. We investigated for evidence of CS in P‐MS and sought to determine its pattern. Methods We used 53BP1, p16, and lipofuscin as markers of CS in white matter lesions (WMLs), normal appearing white matter...

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Share to Genetics, Aging, and Longevity in Model Organisms
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PMID: 39891488
DOI: 10.1002/ana.27195

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