Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels.

doi:10.1002/ijc.33171

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Article

Association of genomic variants at the human leukocyte antigen locus with cervical cancer risk, HPV status and gene expression levels.

International journal of cancer - 1 Nov 2020

Ramachandran Dhanya, Schürmann Peter, Mao Qianqian, Wang Yingying, Bretschneider Lisa-Marie, Speith Lisa-Marie, Hülse Fabienne, Enßen Julia, Bousset Kristine, Jentschke Matthias, Böhmer Gerd, Strauß Hans-Georg, Hirchenhain Christine, Schmidmayr Monika, Tarbiat Johanna, Runnebaum Ingo, Dürst Matthias, Hein Alexander, Koch Martin, Ruebner Matthias, Ekici Arif, Beckmann Matthias W, Fasching Peter A, Luyten Alexander, Petry Karl-Ulrich, Hillemanns Peter, Dörk Thilo

Abstract excerpt

The human leukocyte antigen (HLA) locus on chromosome 6 has been reported to be associated with cervical cancer. We investigated two independent single-nucleotide polymorphisms in a large case-control series of cervical dysplasia and carcinoma that has been newly established by the German Cervigen Consortium, comprising a total of 2481 cases and 1556 healthy females. We find significant associations for both...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Case-Control Studies
Cervix Uteri
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Genetic Loci

Genetic Predisposition to Disease

Germany

HLA Antigens

Human papillomavirus 16

Humans

Middle Aged

Papillomavirus Infections

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 32580243
DOI: 10.1002/ijc.33171

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