Article
Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.
PLoS genetics - 1 Aug 2017
Leo Paul J, Madeleine Margaret M, Wang Sophia, Schwartz Stephen M, Newell Felicity, Pettersson-Kymmer Ulrika, Hemminki Kari, Hallmans Goran, Tiews Sven, Steinberg Winfried, Rader Janet S, Castro Felipe, Safaeian Mahboobeh, Franco Eduardo L, Coutlée François, Ohlsson Claes, Cortes Adrian, Marshall Mhairi, Mukhopadhyay Pamela, Cremin Katie, Johnson Lisa G, Trimble Cornelia L, Garland Suzanne, Tabrizi Sepehr N, Wentzensen Nicolas, Sitas Freddy, Little Julian, Cruickshank Maggie, Frazer Ian H, Hildesheim Allan, Brown Matthew A
Abstract excerpt
A small percentage of women with cervical HPV infection progress to cervical neoplasia, and the risk factors determining progression are incompletely understood. We sought to define the genetic loci involved in cervical neoplasia and to assess its heritability using unbiased unrelated case/control statistical approaches. We demonstrated strong association of cervical neoplasia with risk and protective HLA...
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