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Validation and functional follow-up of cervical cancer risk variants at the HLA locus.

HLA - 1 Aug 2024

Eisenblätter Rieke, Seifert Finja, Schürmann Peter, Beckhaus Theresa, Hanel Patricia, Jentschke Matthias, Böhmer Gerd, Strauß Hans-Georg, Hirchenhain Christine, Schmidmayr Monika, Müller Florian, Hein Alexander, Stuebs Frederik, Koch Martin, Ruebner Matthias, Beckmann Matthias W, Fasching Peter A, Luyten Alexander, Häfner Norman, Hillemanns Peter, Dörk Thilo, Ramachandran Dhanya

Abstract excerpt

Cervical cancer is the fourth most common cancer in females. Genome-wide association studies (GWASs) have proposed cervical cancer susceptibility variants at the HLA locus on chromosome 6p21. To corroborate these findings and investigate their functional impact in cervical tissues and cell lines, we genotyped nine variants from cervical cancer GWASs (rs17190106, rs535777, rs1056429, rs2763979, ,...

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Humans
Uterine Cervical Neoplasms
Female
Genome-Wide Association Study
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide
Genotype
Case-Control Studies
HLA Antigens
Alleles
Middle Aged
Adult
Interferon-gamma
Cell Line, Tumor

Source

Identifiers

PMID: 39101335
DOI: 10.1111/tan.15597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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