Article
GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer.
Human molecular genetics - 5 Jun 2023
Koel Mariann, Võsa Urmo, Jõeloo Maarja, Läll Kristi, Gualdo Natàlia P, Laivuori Hannele, Lemmelä Susanna, Daly Mark, Palta Priit, Mägi Reedik, Laisk Triin
Abstract excerpt
Genome-wide association studies (GWAS) have successfully identified associations for cervical cancer, but the underlying mechanisms of cervical biology and pathology remain uncharacterised. Our GWAS meta-analyses fill this gap, as we characterise the genetic architecture of cervical phenotypes, including cervical ectropion, cervicitis, cervical dysplasia, as well as up to 9229 cases and 490 304 controls for...
Topics
- Humans
- Female
- Genome-Wide Association Study
- Uterine Cervical Neoplasms
- Genetic Predisposition to Disease
- Phenotype
- Risk Assessment
- Polymorphism, Single Nucleotide