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Article

A window into intracellular events in myositis through subcellular proteomics

31 Jan 2025

Abstract excerpt

OBJECTIVE AND DESIGN: Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of inflammatory muscle disorders of unknown etiology. It is postulated that mitochondrial dysfunction and protein aggregation in skeletal muscle contribute to myofiber degeneration. However, molecular pathways that lead to protein aggregation in skeletal muscle are not well defined. SUBJECTS: Here we have isolated...

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PMID: 39890639
DOI: 10.1007/s00011-025-01996-8

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